Methotrexate 2.5 mg tablets

Reason for shortage

Manufacturing delay at Pfizer facility. Multiple rheumatology and oncology indications affected. Do NOT stop without specialist guidance.

What to do

1. 1.
   Contact your pharmacist — Your pharmacist can check current stock levels and advise on nearby pharmacies that may have supply. They can also assist with early dispensing to avoid running out.
2. 2.
   Ask your doctor about alternatives — Your GP or specialist can review whether a therapeutically equivalent alternative is appropriate for your situation. Never switch medicines without medical guidance.
3. 3.
   Request early repeat if eligible — If you have active repeats, your pharmacist may dispense an early repeat to build a short buffer supply while the shortage persists.
4. 4.
   Check TGA for updates — The TGA Medicine Shortage Information (MSI) database is updated regularly with expected resolution dates and approved substitutions.
5. 5.
   Consider compounding if appropriate — For some medicines (particularly oral liquids or specific doses), a compounding pharmacist may be able to prepare an equivalent formulation.

Suggested alternatives

Same or related therapeutic class. Always discuss with your doctor or pharmacist before switching.

• Methotrexate injection — if oral route not essential
• Discuss alternative DMARDs with rheumatologist